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Since most proteins involved in signal transduction are of relatively low abundance, the results indicate that subproteome enrichment improves the sensitivity of identification of low-abundance proteins.
It shows that the predicted complexes by our algorithm can cover the most proteins involved in the real complexes.
Proteins previously identified as disease relevant have significantly more mechanisms assigned than those not previously considered disease relevant (all P values < 0.0001, see Methods), as would be expected if most proteins involved in mechanism have been correctly identified.
By contrast, most proteins involved in housekeeping functions (operational proteins) are considered to evolve faster than those of informational systems, and thus to be less suitable to study ancient evolution.
Interestingly, most proteins involved in translation are very abundant in cells but two reports suggest that eEF1A may be present in only a few hundred copies (Ghaemmaghami et al. 2003; Huh et al. 2003).
Similar(55)
Transcripts for most other proteins involved in glycolysis showed smaller-fold but significant changes in expression, but the directions of the changes were mixed.
Osteopontin (OPN) and Tamm-Horsfall protein (THP) are the most important proteins involved in this process.
Cadherins are one of the most important proteins involved in cell-cell adhesion.
Many of these clients are some of the most important proteins involved in signal transduction pathways.
CaMKII is one of the most studied proteins involved in LTP and memory (Lisman et al., 2002).
On the contrary, most downstream proteins involved in autophagy were detected in P. falciparum and appear to be functional.
Related(20)
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