Interestingly, most Oct4-binding proteins linked to a human hereditary disorder (13 of 14), mostly developmental or cancer predisposition, give rise to a related phenotype when absent in the mouse.
The degree distribution of the network showed that most proteins only linked a few proteins [see Additional file 2], whereas a small quantity of proteins such as three proteins from the family of mitogen-activated protein kinase cascade (i.e. MAP4K3, MAP4K1 and MAP4K5), one serine/threonine kinase (i.e. STK25) linked to more than eighty proteins.
The connectivity distribution P k), the probability that a protein interacts with k other proteins, shown in Figure 1b for the All network, had a heterogeneous, skewed shape, and indicated that most proteins were linked to only a few proteins, but a few proteins had a large number of connections.
We have quantified the number and strength of IP-mediated indirect effects between the five groups of disease proteins and hypothetically identified the most important mediator proteins linking heart disease to obesity or diabetes in the IP network.
How are our proteins linked to our genome?
Scientists will be looking at proteins linked to the flow and regulation of fluids.
This meant that most proteins were very closely linked and the PIN of curcumin was a small world network.
DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a number of diseases, most of which are associated with high oxidative stress.
Another observation linking these proteostasis processes to cancer is that, while most proteins have cellular half-lives of 1 2 h, many Oncogene proteins and TSG proteins have half-lives of a few minutes.
P2Y1 receptors are most commonly linked to proteins of the Gq family and thereby to PLC (Abbracchio et al., 2006).
