Sentence examples for most mutations affecting from inspiring English sources

However, this gene also has many other vital functions, and therefore most mutations affecting fgfr1 supposedly have many negative side effects.

Contrary to most mutations affecting the MLH1 and MSH2 genes, a significant proportion of MSH6 mutations occur in HNPCC families with less typical clinical features.

It is important to recognise that most mutations affecting splicing factors such as SF3B1, U2AF1, and SRSF2 are more likely to cause gain of functions, 9, 33) indicating that they are unlikely to function as tumor suppressors.

Assuming that most mutations affecting phenotype are—at least individually neutral or deleterious (Kimura 1983), if selection against such mutations is weaker in GroEL clients than nonclients due to a buffering effect (Tokuriki and Tawfik 2009a), then clients ought to evolve faster than nonclients.

In this model, whilst most mutations affecting binding of Nm and Hi were located centrally on the CFG face of the protein, Val-39 involved in Opa binding, was located at a distance towards the bottom of the CFG face (Fig. 1A).

On the other hand, the identity of substitution did not seem to be critical in other cases (e.g., most mutations affecting the helical linker connecting the DH and PH domain), indicating a crucial role for the amino acid residue being replaced.

We demonstrated that most mutations affected the activity of HtrA.

Most mutations affect the type V collagen helical domain and lead to a diminished or structurally abnormal type V collagen protein.

A common argument is that most mutations affect stability, whereas only a few are likely to affect function.

Evidence, predominantly from screens of gene knockouts, suggests most mutations affect few traits (Wang et al. 2010; Wagner and Zhang 2011).

Furthermore, while natural variation SNP are shared by multiple individuals and can thus be confirmed through biological replication, most mutations affect a single individual.