Sentence examples for most mutations affect from inspiring English sources

Most mutations affect the type V collagen helical domain and lead to a diminished or structurally abnormal type V collagen protein.

A common argument is that most mutations affect stability, whereas only a few are likely to affect function.

Furthermore, while natural variation SNP are shared by multiple individuals and can thus be confirmed through biological replication, most mutations affect a single individual.

In the uridine turn most mutations affect position U7, which is the only position in the core region that may vary [ 26, 36].

Evidence, predominantly from screens of gene knockouts, suggests most mutations affect few traits (Wang et al. 2010; Wagner and Zhang 2011).

Although many mutants defective for spermatogenesis and/or fertilization have been identified in genetic screens, most mutations affect both male and hermaphrodite sperm equally and none specifically affect male precedence (reviewed in Nishimura and L'Hernault, 2010).

We demonstrated that most mutations affected the activity of HtrA.

However, this gene also has many other vital functions, and therefore most mutations affecting fgfr1 supposedly have many negative side effects.

Contrary to most mutations affecting the MLH1 and MSH2 genes, a significant proportion of MSH6 mutations occur in HNPCC families with less typical clinical features.

On the other hand, the identity of substitution did not seem to be critical in other cases (e.g., most mutations affecting the helical linker connecting the DH and PH domain), indicating a crucial role for the amino acid residue being replaced.

It is important to recognise that most mutations affecting splicing factors such as SF3B1, U2AF1, and SRSF2 are more likely to cause gain of functions, 9, 33) indicating that they are unlikely to function as tumor suppressors.