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The results indicated that IFN-γ was the most important inducer of iNOS in Caco-2 cells.
One of the environmental factors which gained much attention during the last decades, is vitamin D. A poor exposure to either vitamin D or sunlight, its most important inducer, has been associated with a high risk of developing MS [2].
For CYP3A4, carbamazepine is the most important inducer.
IL-1β is the most important inducer of catabolic processes in OA.
VEGF, the most important inducer of angiogenesis, is also under transcriptional control of NF-κB[ 9].
STAT3 has been described to affect the expression of a broad range of angiogenic and angiostatic mediators including basic fibroblast growth factor, matrix metalloproteinase (MMP- 2 and MMP- 2 and the probably best identified and most importand inducer of angiogenesis, vascular endothelial growth factor (VEGF).
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One of the most important inducers of EMT and tumour metastasis is hypoxia [22] and there is growing evidence of a complex interplay between the AKT/PI3K/mTOR pathway and hypoxia [23] [28].
In the clinical setting, the most important inducers of CYP1A2 are polycyclic aromatic hydrocarbons that are present in cigarette smoke.
TGF-β is one of the most important inducers of the myofibroblast phenotype, as well as being an important profibrotic signalling molecule in its own right [ 28].
Neovascularization and angiogenesis are essential features for the progression of a growing tumor VEGF is one of the most important inducers of angiogenesis [ 157].
In this paper, the three most important factors, induction temperature, inducer concentration and organic nitrogen source, were optimized to improve α-pinene production, using the strain YJM28.
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