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Next, we provide a brief recap of the most important computational systems principles related to the new Cloud computing era.

A suitable description of this basis set is provided in some of the most important Computational Chemistry recent books [13 16].

The most important computational burden concerns the HMM learning stage: 23 min 45 s for the entire database on an Intel Xeon CPU E5 1620 0 3.60GHz processor with 16.0 Go RAM.

A scalability analysis of the most important computational kernel inside the code, the parallel sparse matrix vector product, has been performed, as well as an experimental study of the communication overhead.

Identification of the pharmacophoric features is one of the most important computational approaches in a rational drug design process.

To successfully use the machine learning methods to identify PPIs from primary protein amino acids sequences, one of the most important computational challenges is how to effectively represent a protein sequence by a fixed length feature vector in which the important information content of proteins is fully encoded [ 36, 37].

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Most important, our computational analysis of segmental duplications in the human genome suggests that they can be utilized as a novel data source for the analysis of vertebrate point mutagenesis.

This improvement in the computational efficiency is most important, as the computational efforts are much higher when uncertainties are considered.

Computing on graphics processors is maybe one of the most important developments in computational science to happen in decades.

One of the most important models in computational neuroscience is the Hodgkin-Huxley model.

Estimation of small failure probabilities is one of the most important and challenging computational problems in reliability engineering.

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