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Exact(6)
Injection site pain was the most frequent local reaction.
The most frequent local events were pain, bleeding, hematoma and erythema at the injection site.
The most frequent local AE were bleeding, pain on lower abdomen, hematoma, ulcer, necrosis, erythema, and edema on the injection site (Table 2).
In the ID group the most frequent local reactions were erythema and swelling followed by pruritus, whereas pain was reported only in two studies [ 15, 16] and the frequency was similar in the ID and IM group.
The overall incidence of solicited local and general symptoms following primary and booster doses is shown in Table 2. Pain was the most frequent local solicited symptom in both groups.
In 3 studies also subjects with at least one local [ 16– 18] or systemic [ 15– 17] reaction were reported and these values were extracted for the meta-analysis, in others the most frequent local [ 15] or systemic [ 18] reaction was extracted.
Similar(54)
Pain and irritability were the most frequent solicited local and systemic reactions in each vaccine group.
As in the other groups a hematoma was the most frequent postoperative local complication (5.3% after the first and 5.9% after the second surgery).
In both groups, pain was the most frequent solicited local symptom and fever was the most frequent solicited general symptom after the booster dose and each catch-up dose.
Within four days following vaccination, pain was the most frequent solicited local symptom in children aged 2 5 y, which was reported in 45.1% [51/113] of children in the ACWY-TT group and 71.8% [28/39] of children in the Men-PS group (Fig. 2A).
The most frequent AEs were local pain/intolerance to paresthesia (47 subjects, i.e. 2.03%), arousal changes (mostly sleepiness/fatigue, sometimes insomnia, 19 subjects, i.e. 0.82%), headache after the stimulation (12 subjects, i.e. 0.52%).
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