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Long-term studies were also uncommon, with most data coming from experiments lasting 2 3 years.
Even though most data coming from the analysis of completely sequenced genomes and directed-evolution experiments strongly support the patchwork hypothesis, we do not think that all the metabolic pathways arose in the same manner.
3 This is obviously not the case for most data coming from infants and other special populations, which is likely to be much noisier than any of the recordings previously tested with these algorithms.
A recent meta-analysis of published and unpublished data found that the incidence of RSV-associated severe ALRI has ranged from 10 18 per 1000 children/year for infants and 3 9 per 1000 per children <5 years of age/year in Africa, with most data coming from passive, hospital-based surveillance with defined catchment areas [ 44].
Epoetin also improves quality of life (QoL) in anaemic cancer patients; however, only a few randomised studies have shown this (Dammacco et al, 2001; Littlewood et al, 2001; Österborg et al, 2002), with most data coming from large, nonrandomised, community-based studies (Glaspy et al, 1997; Demetri et al, 1998; Gabrilove et al, 2001).
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The consequences of nuclear war on the environment, like its consequences on the balance of power, were difficult to prove; most data came from computer models, and from research on other planets.
Research on the topic is incipient and most data comes from epidemiologic studies, often cross-sectional in design.
For penicillin G and flucloxacillin, most data come from observational, noncontrolled studies often in home-based care settings [45 47].
Comparative literature assessing the relative safety and efficacy of different BoNT products is limited, most data come from reports on small samples, and only a few studies meet criteria of evidence-based medicine.
There is some uncertainty about the biggest blue whale ever found, as most data came from blue whales killed in Antarctic waters during the first half of the twentieth century, which were collected by whalers not well-versed in standard zoological measurement techniques.
There were not many formal field studies examining the difference in ecosystem C cycle between plantations and natural forests, as most data came from the studies that were not established specifically to address this issue.
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