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One of the most critical functional aspects of their function is their ability to remain very selective for K+ over Na+ while allowing high-throughput ion conduction at a rate close to the diffusion limit.
This research finds that the most critical functional requirements of the e-learning system for instructors can be categorized to two dimensions — instruction presentation and student learning management.
It is interesting to note, however, that some of the most critical functional residues of choline kinases as identified by Yuan et al. are conserved [24].
The most critical functional substrate of the cardiac β-adrenergic pathway is phospholamban (PLN).
Thus, the progressive decrease in β-cell insulin secretion, particularly the first-phase insulin secretion that occurs acutely after an increase in glycemia, is likely the most critical functional β-cell defect in the development of type 2 diabetes.
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One of the most critical aspects in functional treatment of class II patients relates to the possibility of enhancing mandibular growth to a clinically relevant level.
Design to cost is a new product development philosophy that makes the factory cost a marketing requirement— one of the most critical and often-overlooked functional areas is the manufacturing element.
Therefore, clinically, MEG recordings are most useful in mapping critical functional regions, such as the auditory cortex, for brain surgery.
Since we found that the proximal 8 region is the most critical for determining the functional performance of a genomic FRT-like sequence, we grouped all unique FRT-like sequences (581,157 sites) based on the sequence of the first four proximal base pairs of their putative recombinase binding elements (positions −1 to −4 and 1 to 4; Figure 1A).
However, it is difficult to draw any conclusions from the findings of previous studies about which of these roles is the most critical for growth suppression, since functional analyses of the checkpoint and E3 ligase activity of CHFR have only been performed independently of each other thus far [1], [22], [27] [29].
Maintenance is becoming a critical functional area in most types of organizations and systems including construction, manufacturing, transportation, etc.
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