Sentence examples for most complex genetic from inspiring English sources

Africa presents the most complex genetic picture of any continent, with a time depth for mitochondrial DNA (mtDNA) lineages >100,000 years.

Trisomy 21 (Ts21) is among the most complex genetic conditions compatible with human survival past term.

Plant shape had the most complex genetic architecture, being controlled by four QTL with alternating direction of allelic effect.

The traditional approach to capture segments shared identical-by-descent (IBD) using affected families and linkage has generally been less productive in MS and in most complex genetic disorders.

Hirschsprung disease is one of the most complex genetic disorders in terms of the number of modifier genes (Garcia-Barcelo et al. 2009; Tang et al. 2010) known to influence the penetrance of its causative mutations, which has been estimated to be of the order of 50 70 % (Bolk et al. 2000).

Most complex disease genetic studies, including many in IBD, have been beset by poor reproducibility of results and slow progress in identifying disease genes.

Despite the hundreds of common genetic variants associated with complex diseases identified by GWAS, only a small fraction of heritability of most common complex genetic diseases are explained by these genes.

GWAS is a powerful method for the detection of genetic contributions to polygenic diseases, and it has been used to identify genetic predisposition in AIS, which has been recently regarded as one of the most common complex genetic disorders of the musculoskeletal system [ 6, 15].

Like many common diseases, MS has a genetic component; however, as with most complex diseases, the genetic architecture may be influenced by heterogeneity, incomplete penetrance, polygenic inheritance, and environmental factors.

For most complex traits, quantitative genetic theory suggests that epistasis is unlikely to contribute substantially to genetic variation [ 1, 2].

While involvement of the MHC region in chromosome 6p21 is not in question for most AID, the complex genetic architecture of this locus poses a significant analytical challenge.