Sentence examples for most appropriate correction from inspiring English sources

However, a post hoc analysis using the evaluation method for selecting the most appropriate correction method, as in the current study, demonstrated that QTcI more appropriately removed the heart rate dependence, and no correlation between plasma exenatide concentrations and ΔΔQTcI was observed.

Prospectively defined rules were applied for selection of the most appropriate correction method prior to formal statistical analysis.

However, the Bonferroni correction is very conservative and may not be the most appropriate correction method to apply in this circumstance.

The QT correction method that generated the average squared individual slopes closest to zero for placebo and with similar slope of QTc and RR relationship for both placebo and exenatide was then identified as the most appropriate correction method and was therefore selected for use in the primary analysis.

The relationship of QTc with plasma exenatide concentration was assessed using a linear mixed effects model with ΔΔQTc from the most appropriate correction method as the dependent variable, the time-matched on-treatment exenatide plasma concentration as a covariate, and subject intercept and slope as random effects, with an assumption of unstructured covariance matrix.

Log-fold (M) over variance (A) plots (M-A plots) were used to determine the most appropriate background correction method.

Many QT correction methods are available, and selection of the most appropriate QT interval correction factor is a topic of considerable controversy and debate [25, 33, 34].

Under these circumstances, the traditional method of simple subtraction of the control from the active response is the most appropriate method of correction.

QTcP, a population-based method, was identified as the most appropriate heart rate correction and was prespecified for primary analysis.

Importantly, methods for employing specific study procedures and prospectively determining the most appropriate heart rate correction methods for QT assessment of drugs with an inherent heart rate effect are demonstrated and should be widely applicable.

As standard QTc methods, such as Fridericia, Bazett and individualized corrections derived from resting ECGs, are frequently inappropriate for QT assessment during significant heart rate increases, a two stage procedure was implemented to determine the most appropriate heart rate correction method prior to QTc analysis [ 17].