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Most adaptive changes occur more rapidly at the mRNA than at the protein level.
The response in liver peaked at 24 48 hours of fasting in mouse, while most adaptive changes had abated by 72 hours.
However, the adaptive response reached a plateau by generation 15, suggesting that most adaptive changes had occurred within the experimental period (but see [ 47]).
This suggests that most adaptive changes in gene expression are sex-specific and highlights the need for both sexes to be considered in studies of gene regulatory evolution.
The liver markedly differed from the biphasic response pattern in the small intestine (with peaks at 12 and 72 hours) in that its adaptive response peaked at 24 48 hours of fasting, while most adaptive changes had abated by 72 hours.
In analogy to the well-known selection targets at the LCT locus (Tishkoff et al. 2007), the selection signatures we identified in human populations target noncoding polymorphisms, supporting the view that most adaptive changes affect regulatory elements (Grossman et al. 2013).
Similar(53)
Intraspecific differentiation of metallophytes is one of the most striking adaptive changes that result from natural outcrops of heavy metal-rich rock or mining activities [ 1- 3].
It's the ones most adaptive to change".
Like the mammals in the Cretaceous period, Modilals are the species that is meant to conquer and rule the earth, not by being the strongest, but by being the most adaptive to change (Charles Darwin).
Arguably, its transformation into an experience most of us will share -- because of collective efforts to improve sanitation and prevent disease -- represents the most important adaptive change in human history.
Perhaps the most surprising adaptive change to have occurred during the LTEE was the huge increase in fitness of one population due to evolving the ability to metabolize citrate, the "inert" metal chelator present in DM minimal medium.
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Justyna Jupowicz-Kozak
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