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Mice lacking both APP and APLP proteins (triple APP/APLP KO-mice) show early postnatal mortality with severe developmental abnormalities [41], [42], [43], [44], [45].
First, low pathogenic avian influenza virus (LPAIV) strains of the H5 and H7 subtypes, which are known to circulate in wild birds, may become highly pathogenic (HPAI) if introduced into poultry and cause high morbidity and mortality with severe economic consequences [1].
It is also important in embryogenesis; p57 Kip2 -null mice exhibit high neonatal mortality with severe developmental defects [ 40].
Our result was similar to a retrospective epidemiological analysis of the ACCORD study, which showed HR of ∼2.87 for all-cause mortality with severe versus not severe episodes of hypoglycemia in a standard treatment group (22).
Figure 1 shows the estimated survival function for patients admitted to the ICU, stratified by HIV status (HIV/HCV group versus HIV group), in the presence of competing risks: (i) ICU mortality with severe sepsis, and (ii) ICU mortality from other causes (without severe sepsis).
Also, the combination of arrest duration, Glasgow Coma Score and noncontrast brain CT findings on admission was a strong predictor of mortality with severe neurological disability, showing a 100% specificity and positive predictive value [ 67]; however, the quite small cohort population and the absence of clear recommendation for withdrawal of care are major confounders for this study.
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Similarly, using US national data, Gaieski and colleagues observed twofold variations in hospital severe sepsis mortality with differing severe sepsis definitions [ 7].
The model also includes a function to represent mortality associated with severe drought events.
Coma and the underlying high mortality associated with severe TBI mask these features.
Mortality associated with severe sepsis and septic shock ranges from 20%to30%0% [ 1].
In calculations of expected mortality, patients with severe comorbidity may not match well with the general population.
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