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Findings from the single-centre trial showed reduced mortality with restrictive red blood cell (RBC) transfusion.
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The finding was probably a statistical quirk, and subsequent trials evaluating leukocyte-reduced RBCs have generally not confirmed a mortality benefit with restrictive RBC transfusion strategies (Table 1).
We analysed patients with IHD because benefit from liberal transfusion has not been confirmed [ 1] whereas the latter two subgroups have shown a mortality benefit with restrictive transfusion [ 2].
This showed increased ventilator free days and trends towards reduced mortality with no change in other organ dysfunction with restrictive fluid balance compared to a liberal fluid balance.
In fact, it has been assessed that the proportion of unsafe abortions is higher with restrictive abortion laws causing significant morbidity and mortality.
Using trial sequential analyses on mortality and myocardial infarction, the required information size was not reached, but a 15% relative risk reduction or increase in overall morbidity with restrictive transfusion strategies could be excluded.
However, improvement in patients with restrictive pattern is occasionally seen.
33 Asbestosis is usually associated with dyspnoea, basilar rales and changes in pulmonary function with restrictive or mixed restrictive obstructive patterns, and carbon monoxide diffusion abnormalities.
Recently, a randomized trial [ 8] comparing a liberal with restrictive transfusion pattern in premature infants found that infants had more frequent apnea in the restrictive transfusion group.
Avoid compressing the breast with restrictive clothing.
The dress flaunts mortality with striking immodesty.
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