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The severity of morphological disruption morphology was scored according to an arbitrary index with 0 being normal and 4 being severely disrupted (Table 1).
In the present study, the mitochondria in F20 group showed morphological disruption whereby the sizes were increased, the cristae were disrupted, and the matrixes were hypodense compared to C group.
Because GMR-Gal4 drives expression initially in third instar larvae, we assessed morphological disruption at this stage.
Using this metric, we demonstrated a statistically significant rescue of CagA morphological disruption by co-expression of sqhA21 (Fig. 3G).
Our work in the eye epithelium argued that CagA induces morphological disruption by activating the Rho/MLC pathway.
To assess the degree of morphological disruption, we examined the pattern of actin and ElaV expression in each eye epithelium.
Similar(37)
We show that expression of the H. pylori virulence factor CagA in a model Drosophila melanogaster epithelium induces morphological disruptions including ectopic furrowing.
There were no marked adverse alterations or degeneration of tissues since these vital organs showed normal architectures suggesting no morphological disruptions as compared with the control group.
In the majority of the treated retinas there were rosettes, and in another third, severe morphological disruptions occurred across the entire retina (Fig. 4D,G-I; supplementary material Fig. S5).
In the presence of supraoptimal 1 μM 24-epiBL, importantly, severe OCP lines showed no significant alteration in growth while WT and other control seedlings displayed substantial morphological disruptions including chaotic growth in hypocotyls and cotyledons (compare Figure 5A and 5B) and generally shorter hypocotyls.
The compound caused cell cycle arrest in G1 phase, suppression of cells progressing through S phase, morphological changes, disruption of the mitochondrial membrane depolarization potential, induction of apoptotic markers as well as p38 and JNK MAPK activation, DNA degradation, and elevated generation of reactive oxygen species (ROS) in SMS-KCNR NB cells.
Related(20)
morphological distortion
morphological discontinuity
morphological disorganization
morphological disorder
molecular disruption
morphological perturbation
morphological disarray
morphological alteration
morphological chaos
morphological break
morphological dysfunction
morphological adaptation
morphological pattern
morphological characterization
morphological evolution
morphological difference
morphological filtering
morphological filter
morphological variety
morphological evidence
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