When pTa1-RFP-transfected F11 cells were implanted simultaneously with miR-124a into the nude mice, gradually increasing reporter signals and morphological changes indicated neuronal differentiation for 48 hours in live cells in vitro.
The morphological changes indicated that these cells may undergo EMT.
Comparing these data with observed morphological changes indicates that the largest change in transcriptome state of any time in development coincides with the transition from aggregates to multicellularity.
Muscle morphological changes indicate the importance of primary fiber formation from 30 to 40 dpc (days post coitus), and secondary fiber formation from 55 to 70 dpc.
According to previous reports, these morphological changes indicated that mitochondrial fragmentation was involved in the hepatotoxicity of Cd, which may lead to mitochondrial damage through hampering the mixture and exchange of mitochondrial contents.
Substantia nigra neurons, whether they contain Lewy bodies or not, are similarly affected, for example, by morphological dendritic abnormalities or biochemical changes, indicating that the neurons in general are involved in the disease process [ 11, 52, 61, 113].
