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In a posterior work, Shea and Bailey [31] evaluated body proportions in order to test the hypothesis that morphologic differentiation of African pygmies can be explained by the differential extension of a common growth pattern (i.e. ontogenetic scaling).
WT1 expression was restricted to the cytoplasm of sympathetic neuroblasts, while it progressively disappeared with advancing morphologic differentiation of these cells along both ganglionic and chromaffin cell lineages.
First, we described the development of crown architecture by following the growth of the crown in 15 young individuals, with special attention to growth and branching models and to the morphologic differentiation of axes.
Morphologic differentiation of neurons involves dynamic processes.
Subsequent masculinization of the reproductive tract occurs with the morphologic differentiation of the epididymis, vas deferens, seminal vesicles, and prostate, as well as external genitalia (penis, scrotum, and perineum).
Intrahepatic transplantation of WB cells, which are liver bipolar stem cells, into adult syngenic F344 rats results in the morphologic differentiation of these cells into hepatocytes and incorporation into hepatic plates (Coleman et al. 1993).
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Distinct subsets of adenocarcinoma with morphologic differentiation to type II pneumocytes, Clara cells, or non-ciliated bronchioles are thought to originate from the terminal respiratory unit (TRU), and EGFR mutation is involved with early-stage carcinogenesis of TRU-type adenocarcinoma [ 5, 37]; nGGOs appear to be another marker of TRU-type adenocarcinoma [ 5].
The most striking effect of BAP1 loss was the induction of a primitive, stem-like phenotype characterized by a loss of morphologic differentiation, down-regulation of the melanocyte transcriptional program, up-regulation of genes enriched in stem cells and developmental processes, and enhanced growth capacity under stem cell conditions.
The degree of morphologic differentiation was reflected by the levels of mucin and constitutive E-cadherin expression.
Human liver cell lines IHH, HepG2, HuH-7 and JHH-6 were used as in vitro models of HCC cell lines with different degree of morphologic differentiation.
All tissues showed a similar degree of morphologic differentiation and thickness that was similar to control tissues that developed in the presence of mature fibroblasts (Figure 5A).
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