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Signet-ring cell lymphoma (SRCL) is a rare morphologic variant of non Hodgkin lymphoma.
Although it was initially reported as a rare morphologic variant of follicular lymphoma (FL), SRCL has to date been described in most types of non Hodgkin lymphoma, mostly as single-case reports.
Adenocarcinoma with micropapillary component is a morphologic variant of carcinoma and usually recognized as a poor prognostic predictors [ 15].
Someone uninitiated in tumor biology may infer that the goblet cell carcinoid is a morphologic variant of an indolent neoplasm undeserving of any special designation.
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Several morphologic variants of PLE have been described, including a localized form of PLE primarily affecting the helices of the ears.
Several morphologic variants of schwannoma are recognized, that is, conventional, cellular, microcystic/reticular, plexiform, and melanotic schwannoma [ 1, 2].
In addition, the morphologic variants of FSGS fall short in distinguishing primary from secondary forms of FSGS.
A number of morphologic variants of primary and secondary focal sclerosis are now recognized, based on a 2004 Columbia classification system, including FSGS-not otherwise specified (NOS), perihilar, cellular, tip, and collapsing variants.
Regarding the correlation between the morphologic variants of DLBCL NOS and GEP, a single study demonstrated that the immunoblastic subtype was enriched for cases with an ABC profile, whereas purely centroblastic neoplasms were more often GCB [ 24].
The two subgroups did not differ histomorphologically for criteria such as pronounced nuclear pleomorphism, prominent nucleoli, a rim of basophilic cytoplasm, diffused or focal cluster distributions and morphologic variants of large cells.
Awareness of this morphologic variant could prevent the misdiagnosis of "ganglioglioma with an oligodendroglioma component", averting the potential risk of under-treating these patients.
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