more somatic mutations

USAGE SUMMARY

The phrase "more somatic mutations" is correct and usable in written English.
It can be used in contexts discussing genetics, cancer research, or evolutionary biology, where the frequency or quantity of somatic mutations is being compared or analyzed. Example: "The study revealed that patients with advanced cancer had more somatic mutations than those in the early stages of the disease."

✓ Grammatically correct

Science

Genetics

Cancer Research

Human-verified examples from authoritative sources

Exact Expressions

15 human-written examples

Smokers have more somatic mutations than non-smoker patients39, raising the possibility that mutation burdens may link to AhR levels.

Nature

We found that patients with clinical benefit harbored more somatic mutations (median = 496) as compared to those without clinical benefit (median = 169), (P = 0.01, Mann Whitney test, Fig. 2b).

Nature

For the exome data, MuTect and Strelka detected more somatic mutations than the other methods.

BMC Genomics

A common approach to this problem is to identify genes that harbor significantly more somatic mutations than expected by chance.

Bioinformatics

The advent of cancer genomics has shown that there are far more somatic mutations than hitherto imagined.

British Journal of Cancer

On the contrary, while MuTect identified more somatic mutations, only 16%% of these fall into gene coding regions (usually with lower coverage and/or mutation frequencies).

Genome Medicine

Human-verified similar examples from authoritative sources

Similar Expressions

45 human-written examples

Indeed, 56% (28 out of 50) of the endometrial tumours were found to carry one or more somatic mtDNA mutations including deletions, point mutations and mtMSI.

British Journal of Cancer

More recently, somatic mutations in ERBB2 have been reported in 1% to 2% of patients with lung adenocarcinoma.

Stanford University

This enlargement of GC could ultimately lead to more Ig somatic mutations and higher Ig affinity.

EMBO Molecular Medicine

In theory, classifiers that predict more true somatic mutations should show higher concordance with the database of somatic mutations and lower concordance with the germline database.

Bioinformatics

Mutation of PTEN is one of the more common somatic mutations in human cancer and is found particularly in ovarian, prostate and glioblastoma cancers.

Breast Cancer Research

Expert writing Tips

Best practice

When comparing mutation rates between different groups, specify the context (e.g., "tumors from smokers showed "more somatic mutations" than those from non-smokers").

Common error

Ensure that the baseline for comparison is clearly stated to avoid ambiguity. For example, instead of stating "samples showed "more somatic mutations"", specify what it is more than, such as "compared to healthy tissue".

Linguistic Context

The phrase "more somatic mutations" functions primarily as a comparative descriptor. It indicates a greater quantity or frequency of somatic mutations in one context compared to another. Ludwig's examples highlight its use in comparing mutation burdens in different groups, such as smokers vs. non-smokers.

Expression frequency: Common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, the phrase "more somatic mutations" is a grammatically correct and commonly used comparative descriptor primarily found in scientific and academic contexts. According to Ludwig, it effectively communicates a greater frequency or quantity of somatic mutations and is used for comparisons between different groups or conditions. When using this phrase, ensure the comparison baseline is clear to avoid ambiguity. Consider alternatives like "increased somatic mutations" for variety. In short, it's important to express clearly the context around this comparison for an effective communication.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

increased somatic mutations

Replaces "more" with "increased", focusing on the rise in somatic mutations.

higher number of somatic mutations

Substitutes "more" with "higher number of", emphasizing the quantity of somatic mutations.

greater quantity of somatic mutations

Replaces "more" with "greater quantity of", highlighting the amount of somatic mutations.

elevated levels of somatic mutations

Uses "elevated levels of" instead of "more", indicating a rise in somatic mutation presence.

disproportionate somatic mutations

Implies an imbalance or unexpected amount of somatic mutations compared to a baseline.

excess of somatic mutations

Expresses that there's an excessive amount of somatic mutations.

augmented somatic mutations

Uses "augmented" to show that somatic mutations have been increased.

a surplus of somatic mutations

Replaces "more" with "a surplus of", indicating an overabundance of mutations.

additional somatic mutations

Suggests the presence of extra or supplementary somatic mutations.

enhanced somatic mutations

Replaces "more" with "enhanced" describing the mutations have been made stronger.

FAQs

How is the phrase "more somatic mutations" used in scientific writing?

In scientific writing, "more somatic mutations" is commonly used to compare mutation burdens between different samples, conditions, or groups, especially in the context of cancer research, genetics, and evolutionary biology. For example, researchers might compare mutation rates between different tumor types, individuals with varying exposures to mutagens, or populations evolving under different selection pressures.

What are some alternatives to the phrase "more somatic mutations"?

You can use alternatives like "increased somatic mutations", "higher number of somatic mutations", or "greater quantity of somatic mutations" depending on the specific context and emphasis you wish to convey.

What factors might lead to "more somatic mutations" in a cell or organism?

Several factors can contribute to "more somatic mutations", including exposure to mutagens (e.g., radiation, chemicals), errors during DNA replication or repair, defects in DNA repair mechanisms, and certain genetic predispositions. Additionally, aging and increased cell division can lead to a greater accumulation of somatic mutations over time.

How does having "more somatic mutations" affect the risk of cancer?

Generally, having "more somatic mutations" increases the risk of cancer because these mutations can disrupt the normal function of genes involved in cell growth, division, and DNA repair. The accumulation of multiple mutations in key genes can lead to uncontrolled cell proliferation and the development of tumors.