increased somatic mutations

USAGE SUMMARY

The phrase "increased somatic mutations" is correct and usable in written English.
It can be used in scientific or medical contexts when discussing the rise in genetic changes that occur in the body's cells. Example: "Research has shown that increased somatic mutations can lead to a higher risk of developing certain cancers."

✓ Grammatically correct

Science

Academia

Human-verified examples from authoritative sources

Exact Expressions

2 human-written examples

While the importance of individual genetic makeup (intrinsic factors) in longevity and delayed onset of diseases is logical, how the confounding extrinsic factors such as the interactions of oxidative stress and aging process would lead to increased somatic mutations that affect the regulations of biological clocks and functions of organ systems in the direction of diseases are not understood.

Clinical and Translational Medicine

The acquisition of these transformed characteristics is thought to be aided by increased somatic mutations caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced endogenously within the inflamed joint [ 4].

Arthritis Research and Therapy

Human-verified similar examples from authoritative sources

Similar Expressions

58 human-written examples

Compared to the other samples, the PCa BRCA2-deficient tumors exhibited a complex and highly specific mutation signature, featuring a 2.88-fold increased somatic mutation rate, depletion of context-specific C>T substitutions, and an enrichment for deletions, especially those longer than 10 bp.

The American Journal of Human Genetics

Both conditions may lead to increased somatic mutation in these cell populations.

F1000Research

Aberrant expression of viral oncoproteins may therefore promote tumourigenesis through increased somatic mutation and aneuploidy due to DDR inactivation.

British Journal of Cancer

In addition, the mtgenome has a high copy number and an increased somatic mutation rate in comparison to its nuclear counterpart, providing multiple target copies with target markers.

BioMed Research International

Four types of effects were originally reported in multiple studies: increased spontaneous abortion, shifts in red and white blood cell counts, increased somatic mutation rates in lymphocytes, and increased childhood, testicular, and other cancers.

Environmental Health Perspectives

Below we discuss molecular mechanisms that may increase somatic mutations during aging.

Cell Stem Cell

Increasing somatic mutation of IgG4 members of a clone was seen in immunotherapy, whereas IgE mutation levels in the clone did not increase.Most peanut allergen-binding B cells isolated by means of antigen-specific flow sorting express mutated and isotype-switched antibodies.

Stanford University

The detection of increased somatic mtDNA mutations in RA tissue is clearly intriguing and raises many questions that have yet to be analyzed.

Arthritis Research and Therapy

α is the multiplicative factor by which a mutator mutation increases the somatic mutation rate per cell generation, e.g. the magnitude of the genetic instability.

Plosone

Expert writing Tips

Best practice

When discussing research findings, clearly specify the context in which "increased somatic mutations" were observed, such as tissue type, disease state, or experimental conditions.

Common error

Do not simply state that "increased somatic mutations" are present without providing quantitative data or specifying the genes or regions affected. Provide specific details to support your claims.

Linguistic Context

The phrase "increased somatic mutations" functions primarily as a noun phrase, where "increased" acts as a modifier describing the extent of "somatic mutations". According to Ludwig, this phrase is grammatically correct and usable in written English.

Expression frequency: Common

Frequent in

Science

66.66%

Academia

33.33%

News & Media

0%

Less common in

Formal & Business

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, the phrase "increased somatic mutations" is a grammatically sound and commonly used term, primarily found in scientific and academic contexts. It serves to describe a higher incidence of genetic changes in somatic cells, often linked to research or medical findings. Ludwig AI confirms its correct usage and provides relevant examples. While alternatives such as "elevated somatic mutations" exist, the original phrase remains a clear and effective choice in scientific writing.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

elevated somatic mutations

Replaces "increased" with "elevated", implying a similar rise in somatic mutations.

heightened somatic mutations

Substitutes "increased" with "heightened", suggesting a similar elevation in somatic mutations.

greater somatic mutation rate

Focuses on the "rate" of mutation, rather than the absolute increase, but conveys a similar concept.

augmented somatic mutations

Uses "augmented" instead of "increased", indicating an amplified presence of somatic mutations.

amplified somatic mutations

Implies somatic mutations have been intensified or grown significantly.

enhanced somatic mutations

Replaces "increased" with "enhanced", suggesting somatic mutations have been strengthened or improved.

elevated level of somatic mutations

This alternative phrase specifically mentions the "level" of somatic mutations, providing a more explicit description of the change.

intensified somatic mutations

Uses "intensified" instead of "increased", indicating a heightened presence of somatic mutations.

more frequent somatic mutations

Replaces "increased" with "more frequent", focusing on the occurrence of somatic mutations.

rising somatic mutation burden

Shifts focus to the "burden" of mutations, describing a growing accumulation of somatic mutations.

FAQs

How do I use "increased somatic mutations" in a sentence?

You can use "increased somatic mutations" to describe a higher rate or number of genetic changes in cells, such as in the sentence, "Research indicates that exposure to certain chemicals can lead to "increased somatic mutations" in lung cells".

What is the significance of "increased somatic mutations" in cancer?

In cancer, "increased somatic mutations" can drive tumor development and progression by altering gene function and cellular behavior.

What factors can lead to "increased somatic mutations"?

Factors such as aging, exposure to radiation, certain chemicals, and viral infections can contribute to "increased somatic mutations".

Are "increased somatic mutations" always harmful?

While often associated with disease, not all "increased somatic mutations" are harmful; some may have no effect or even provide a selective advantage in certain contexts.