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Various estimates of the more sensitive model parameters spanned in a small neighborhood of the optimal parameter estimates (see Ref. [1] for details).
The ever-changing state of the embryo makes it a more sensitive model for toxicity and a better predictor of long-term, delayed effects.
Reports of congenital anomalies were obtained from vital records and a more sensitive model of the water distribution system estimated prenatal exposures in the follow-up study.
HepG2 cells were more sensitive in terms of the magnitude of regulation, and also in the terms of the total number of differentially regulated genes, and may be a more sensitive model for assessing TCDD exposure [ 27].
When gender effect was adjusted for in the model, a more sensitive model (increase of 5.04%) was afforded by stepPLR (λ = 1,10) while mob provided a more specific (increase of 3.81%) model due to the inclusion of age (Table 1).
However, when this analysis was repeated using a more sensitive model of the water distribution system and with data on fetal deaths obtained from the Massachusetts Registry of Vital Records (losses ≥20 weeks or fetuses weighing ≥350 g) rather than self-reported by the participants, women with the greatest exposure had 2.6-times the risk of stillbirth (95% CI: 0.7, 8.9) as unexposed women [ 2].
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"The results we found do not guarantee that the more sensitive models are correct," he said.
Our framework can be used as a checklist to assess which capacity phenomena are considered in an assignment model and to inspire the development of more sensitive models.
IPD adds more power by controlling for between study confounders and by enabling more sensitive modelling of the age-effect relationship [ 31].
Other rat strains, such as the Sprague-Dawley and Wistar Han, have a lower spontaneous incidence of Leydig cell tumors (∼ 5%), making them potentially more sensitive models (NTP 2005a).
On the other hand, sometimes very high concentrations used in in vitro models suggest caution in the interpretation of in vitro results and again points to the development of more sensitive models.
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