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"The results we found do not guarantee that the more sensitive models are correct," he said.
Our framework can be used as a checklist to assess which capacity phenomena are considered in an assignment model and to inspire the development of more sensitive models.
On the other hand, sometimes very high concentrations used in in vitro models suggest caution in the interpretation of in vitro results and again points to the development of more sensitive models.
Other rat strains, such as the Sprague-Dawley and Wistar Han, have a lower spontaneous incidence of Leydig cell tumors (∼ 5%), making them potentially more sensitive models (NTP 2005a).
Iterated HMM is shown to be able to build a more diverse and potentially more sensitive models than regular HMM, by incorporating distant homologous sequences while avoiding the contamination of non-homologous sequences into the model [ 62], and thus iterative HMM has been frequently utilized in bioinformatics and computational biology [ 63- 66].
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Various estimates of the more sensitive model parameters spanned in a small neighborhood of the optimal parameter estimates (see Ref. [1] for details).
IPD adds more power by controlling for between study confounders and by enabling more sensitive modelling of the age-effect relationship [ 31].
The ever-changing state of the embryo makes it a more sensitive model for toxicity and a better predictor of long-term, delayed effects.
Reports of congenital anomalies were obtained from vital records and a more sensitive model of the water distribution system estimated prenatal exposures in the follow-up study.
HepG2 cells were more sensitive in terms of the magnitude of regulation, and also in the terms of the total number of differentially regulated genes, and may be a more sensitive model for assessing TCDD exposure [ 27].
When gender effect was adjusted for in the model, a more sensitive model (increase of 5.04%) was afforded by stepPLR (λ = 1,10) while mob provided a more specific (increase of 3.81%) model due to the inclusion of age (Table 1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com