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Exact(5)
Similarly, in the present study, the identified QTL have specificity in terms of direction of effect (whether the allele derived from the more resistant line had a positive of negative effect on resistance) and magnitude of effect.
However, in more resistant line A birds the host defense responses were characterized by an up-regulation lymphocyte activation, probably by regulatory T cells and an increased expression of the NLR recognition receptor NALP1.
Of these, 7 originated from the more resistant line, and one from the less resistant line.
In addition, we have shown increased mRNA expression levels of pro-inflammatory cytokines in heterophils isolated from the more resistant line compared to the susceptible line [ 11, 12, 14].
Of the 21 QTLR, 14 presented positive effects, indicating that the resistant allele originated from Line 2 (the more resistant line), and 7 presented negative effects, indicating that the resistant allele originated from Line 1 (the less resistant line).
Similar(55)
In short, two inbred chicken lines differing in susceptibility to gut pathogens (lines N and 6, with line 6 more resistant than line N, [ 29]) were at three weeks of age orally infected with 5.1x10-1.97x10 cfu S.
The two broiler lines used in this study have been evaluated in Salmonella, Enterococcus and C. jejuni challenge studies [7], [25], [26], [27] and in all instances chickens from line A were more resistant than line B chickens.
However, under the same challenge protocol as the present study, Line 2 was distinctly more resistant than Line 1.
In contrast, BxPc3, which is a more resistant cell line to IGF-IR inhibition (IC50 = 1.54 μM), exhibited more than 30% increase in growth following treatment with the same ligands.
Test of BPH response showed that lines with three gene combined were more resistant than lines with two genes or lines with single genes.
Interestingly, the more resistant cell line U251-MG expresses higher levels of Wee1, followed by LN229 cells and the U87-MG cells.
Related(17)
more robust line
more tolerant line
more susceptible line
more pragmatic line
more cautious line
more sceptical line
more clean line
more controversial line
more iconic line
more independent line
more nuanced line
more fundamental line
more promising line
more insightful line
more indirect line
more resistant state
more serious line
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