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Checking cross references from this review, four more randomized trials were identified [11, 12, 13, 14].
More randomized trials are, however, needed to further support this type of approach and to demonstrate that this strategy improves short- and long-term outcome.
Guidelines on breast and ovarian cancer utilized significantly more randomized trials and meta-analyses.
This is not surprising, given that there are far more randomized trials and meta-analyses performed for advanced breast and ovarian cancer than for cervical and endometrial cancer.
We addressed the utilization of randomized evidence within the guidelines by recording whether guidelines cited within their reference list any randomized trials and meta-analyses pertinent to the chemotherapy question and, if so, how many; and whether they made a comment on the need for more randomized trials to provide sufficient guidance.
More randomized trials are needed to determine the optimal approach.
Similar(51)
This is not a call for more randomized controlled trials, however, since randomizing clients is not often appropriate, due to the fundamental principle of client choice in FP and GBV programming [ 54].
Continuous outcome measures can enable smaller, more efficient randomized trials and randomized trials are generally more informative than single-arm studies with historical controls.
In addition, more randomized controlled trials with a large sample to test not only the efficacy of HA versus the other established therapies of OA, but also the different products, dosages and the optimal number of injections.
"You would think at this point that you would either abandon the idea or do some more randomized controlled trials," he added.
More randomized controlled trials should be carried out to compare LITT to other ablative techniques and to investigate the role of LITT in combination therapy.
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