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Most of the clinical scientists I know fall into the trap that one more randomized clinical trial will settle a particular question once and for all.
More randomized clinical trials need to be completed in order to demonstrate the efficacy, safety, and benefits of MSCs in treating patients with OA.
Although many factors influence disease control, nonetheless the heterogeneity in beliefs also raises concern over the extent to which a broadly consistent approach is currently being achieved; it supports the argument for more randomized clinical trials and for national programs to control nonstatutory endemic diseases.
The authors emphasize the need for more randomized clinical trials to address this topic.
Perhaps the answer is not more randomized clinical trials but better adherence to current guidelines and treatment recommendations.
Perhaps we should look inwards: the answer may not be more randomized clinical trials, but better adherence to current guidelines and treatment recommendations.
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More randomized controlled clinical trials, with low risk of bias and larger samples, are necessary to further investigate if there are actual clinical and radiographic advantages of using EMD for periodontal regenerative therapy.
Although current evidence suggests that LB use does not reduce the risk of a first episode of low back pain [ 1, 2], there may be a role for LBs for secondary and tertiary prevention, as suggested by a systematic review showing more controversial findings for patients with low back pain [ 1] and the positive clinical findings observed in the more recent randomized clinical trials (RCTs) [ 41, 42].
Since this is just a small pilot study, more randomized controlled clinical trials with large samples are needed to prove it, including studies with patients of more skin types and multiple treatment parameters.
The study published today is an observational study, and officials at GlaxoSmithKline, which manufactures rosiglitazone, dismissed the findings, saying they are inconsistent with evidence from more rigorous randomized clinical trials.
7 We have performed a systematic review to assess the validity of the current data, including more recent randomized clinical trials and observational studies that provide a broad-based view of the effect of exercise on cognition in elderly persons.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com