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High IR may be associated with more persistent arterial occlusions and worse long-term outcome after acute ischemic stroke thrombolysis.
We hypothesized that high IR is associated with more persistent arterial occlusions and poorer long-term outcome after stroke thrombolysis.
Having a HOMA-IR in the upper tertile level was associated with more persistent arterial occlusions after thrombolysis.
Considering the pathophysiological background and our previous research, we designed a prospective study to test the hypothesis that a high IR is associated with a worse clinical outcome and more persistent arterial occlusions after intravenous thrombolysis for acute ischemic stroke.
IR may lead to a derangement of endogenous fibrinolisis, increased clot density, and prolonged lysis times as reflected by more persistent arterial occlusions, thus becoming a promising therapeutic target.
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