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Exact(5)
Such a result could be explained if one or more gene conversion events between paralogues had occurred during their evolution.
Supporting this interpretation, Gay et al. (2007) found ∼1.5× more gene conversion than expected from crossovers alone in a region of human chromosome 1.
GC-rich regions often trigger gene recombination, suggesting that the Chinese alligator might undergo more gene conversion events than other amniotes.
Given this hypothesis, it is suggestive that many of the RP ohnologs are very similar in sequence; in fact, it is thought that these genes have undergone one or more gene conversion events post-WGD (Kellis et al. 2004).
This result suggests these genes are evolving so rapidly that orthology is difficult to detect, that they undergo more gene conversion which obscures orthology, and/or that they experience higher rates of gene birth and death.
Similar(55)
As with nontandemly repeated DNA, there is a paradox in that the more rapid gene conversion is, the more difficult it becomes to detect conversion events involving duplicated microsatellites, because the process will tend to homogenize the two copies.
However, the possibility of more intensive gene conversion between these intergenic segments resulting in higher intraspecies similarity cannot be excluded.
Particularly, more frequent gene conversions in inverted repeat (IR) than in single copy (SC) regions result in contrasting substitution rates between these two regions.
If heart enhancers underwent more GC-biased gene conversion events, they would be predicted to have a higher NA/T→G/C to Nsubstituted A/T ratio.
In combination, the results shown in Figure 2 indicate that heart enhancers did not experience more GC-biased gene conversion events over their evolution.
This approach has the advantage that it is more rapid than gene conversion, but the disadvantage that PREs are subject to genomic position effects [ 4, 5, 19].
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