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The links between reproduction, lipid metabolism and ageing are more extensively discussed in the revised manuscript (first and third Discussion sections).
These aspects will be more extensively discussed in a separate article currently in preparation.
The technique of phage display and its applications is more extensively discussed in some recent review papers.
Functional analysis of such mutations as demonstrated here will allow to determine the putative pathogenic nature of some of these mutations as more extensively discussed in (Guerreiro et al, 2010).
In addition, we have now more extensively discussed why we may not have detected a stronger difference and explain this with the enhanced lignification in the vascular tissue only Reviewer #2 comments: This manuscript describes a possible mechanism by which the maize fungus Ustilago maydis induces accumulation of anthocyanins as a mechanism to prevent lignin formation.
For about 10 years, in parallel with the technical improvement of oocyte freezing, the possibility of egg storing for nonmedical purposes is more extensively discussed and more commonly accepted by the general population and expert committees in the USA and Europe.
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In the revised manuscript we now more extensively discuss the prior work by Guanella/Verschure and Balasubramanian's group.
The recommendations were extensively discussed during a 2-day meeting gathering more than 60 experts from different continents, including six patient representatives.
Since the establishment of the first human pluripotent stem cell lines more than a decade ago the therapeutic potential of stem cells has been extensively discussed.
The issue has been extensively discussed in a recent paper [ 33] concluding that more effort should be made to investigate whether disadvantaged people are more vulnerable, i.e. risks differ in different social groups living in the same area.
This result has been extensively discussed.
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