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In follow-up studies 28% of those SLE patients developed new or more extensive plaque over approximately 3 years, with plaque progression associated with increased homocysteine levels [ 65].

For example, several studies show a significant inverse correlation with MMSE scores, suggesting that lower scores associated with dementia are linked to more extensive plaque formation [ 2, 13, 20, 58].

Second, compared to non-diabetic individuals, DM patients have a more extensive plaque burden, as shown in several previous studies [ 6, 21] and confirmed by our results, which has a strong influence on MDCT diagnostic accuracy [ 22].

The more extensive plaque development in the larger brachiocephalic arteries might be more dependent on an efficient migration of smooth muscle cells, in comparison to plaques developing in the carotids.

Similar(56)

Subsequent groups of rats injected with the infected brain material had more pronounced symptoms of cerebellar dysfunction (problems with posture and movement), more extensive plaques with misfolded PrP, and cerebellar lesions.

Thereafter, a more extensive analysis of plaque burden was obtained by registering the total number of atherosclerotic plaques and obstructive plaques for each patient (10).

Diabetes leads to more extensive neointimal hyperplasia, plaque formation, altered hemodynamics and inadequate compensatory remodeling (table 1) [ 8].

Thus, crossing Hmox1−/− mice with atherosclerosis prone ApoE-/ animals resulted in more extensive and complex plaques, while HO-1 induction impeded atherogenesis and stabilized plaques.

More extensive neointimal hyperplasia and more rapid plaque formation in diabetics leads to more restenosis and less stable atherosclerotic plaques.

More extensive data on the specific characteristics of atheromatous plaques and difference between subgroups is beyond the aim of this article, and it has partially been published [ 48].

Recent studies using intravascular ultrasound (IVUS) to evaluate coronary plaque burden in diabetic patients could show more extensive atherosclerosis [ 20- 22].

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