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Use of AFLP and SRAP markers provided more extensive marker densities [ 39, 40].
It should be noted that genotyping outbred mice or mice of mixed backgrounds is possible, but may require the use of a more extensive marker panel.
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It can be anticipated that future developments will include the use of more extensive markers of synovial inflammation and joint degradation as well as the use of panels of biomarkers in serum and synovial tissue samples.
Inevitably, bees just try harder when they've found a suitable habitat, leaving a more extensive scent marker and eventually, a more extensive infestation.
Our case was milder, but it still demonstrates certain aggressiveness including infiltration into the muscle and intestine, and more extensive positive markers (EMA and vimentin) and necrosis.
Future interest in other conditions, or in the identification of more extensive polymorphic markers for comparing populations, will be able to use this assembly as a reference to improve and focus effort on the condition of interest.
The data generated is not only valuable for addressing these evolutionary questions, but can also be used by the wider rust research community for development of more extensive polymorphic markers for large-scale screening of PST field populations and to complement the current set of dominant AFLP markers.
BT10 exposure causes a more extensive expansion of this marker compared to ATRA (although note that BT10 is used in this experiment at a much higher concentration compared to ATRA, which is overall more active).
More extensive studies on UPR markers are required to determine the role of the UPR in repeat expansion diseases.
In this case, the binding of pimonidazole was more extensive than the intrinsic markers, but this was variable between tumours.
A detailed analysis of these tumours, using a more extensive panel of IHC markers to delineate the basal phenotype, is warranted.
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