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More extensive bone marrow involvement would be considered stage 4 disease.
An additional repair process in cases of more extensive bone stress is a periosteal reaction where the periosteum begins to thicken and offers additional mechanical support.
Furthermore, double-bundle ACL reconstruction creates more extensive bone loss and requires longer operative times, thereby potentially increasing the difficulty of revision surgery.
To obtain more extensive bone formation in composites of porous ceramics and bone marrow stromal cells (BMSCs), we hypothesized that a low-pressure system would serve to facilitate the perfusion of larger number of BMSCs into the porous scaffold, enhancing bone formation within the composites.
As the angiogenic factor vascular endothelial growth factor (VEGF) regulates osteoclast activity and is associated with more extensive bone metastases and SRE risk in metastatic breast cancer, we hypothesized that blockade of VEGF signaling could be a therapeutic strategy for inhibiting bone metastases progression and possibly prolonging overall (OS) or progression-free survival (PFS).
Immobilization was not applied until further MRI of both feet demonstrated more extensive bone marrow edema in the right than the left midfoot.
Similar(53)
An MRI demonstrated more extensive midfoot bone marrow edema and collapse of the intermediate and medial cuneiform bones.
This has been exemplified in a model of Porphyromonas gingivalis-induced periodontitis, where MMP-8 knockout mice suffered a more extensive alveolar bone loss than wild-type mice (Kuula et al. 2009).
This certainly seems probable since a recent study has demonstrated that prostate tumours-expressing high levels of Dkk-1 produce more extensive local bone destruction compared to controls that express lower levels (Hall et al, 2005).
Histomorphometric analysis revealed more uniform and extensive bone formation in the low pressure group than in the controls.
Consequently, more extensive surgical exposure, bone debris, and longer operative time in hip resurfacing are not likely to be absolute risk factors for heterotopic ossification.
Related(20)
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