In more complex cases of a substantial bone defect with concomitant poor-vascularized soft tissue, the use of an osseocutaneous-free flap is a viable alternative (Fig. 10d).
It was concluded that optimal fracture efficacy most likely required more substantial increases in BMD, as well as more pronounced suppression of bone turnover and that this required higher iv doses of ibandronate.
To charge someone with felony assault, which carries more substantial punishment than a misdemeanor, the victim usually needs to have evidence of serious bodily injury, like broken bones or cuts.
The reason for these differences may be that patients with bone metastases are a more heterogeneous group including those with one or two bone metastases as well as patients with massive engagement and prerequisites of substantial bone marrow infiltration.
Carrie Rickey of The Philadelphia Inquirer said that "those who want something more substantial from a movie than a vid-game script with centerfold appeal will not find it in this noisy, bone-crushing survivalist flick".
More substantial!" Pavarotti said.
Or something more substantial?
It is time for something more substantial.
The markets had wanted something more substantial.
More substantial progress may take a generation.
