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Cerebral inflammation can eventually disrupt the BBB further by more extensive activation of resident cells like astrocytes and microglia, and infiltration of inflammatory cells, macrophages and leukocytes.

A second-level group comparison illustrated stronger and more extensive activation in the 60 included subjects than the 38 excluded subjects (see Supplementary Fig. 2).

The elevated rCBF in the visual cortex of phobics in response to their feared object [ 9, 10] is in line with studies reporting more extensive activation of the visual cortex when viewing highly emotional (arousing) stimuli [e.g., [ 16, 17]].

Crucially, the Wernicke's aphasia group showed significantly greater and more extensive activation than the control group throughout the ventral and superior anterior temporal lobe; activation increased in the anterior temporal lobe and other regions following lesions to posterior temporal regions classically associated with semantic representation access.

First, increasing values of word frequency and imageability were expected to produce increasing activation in semantic regions such as the angular gyrus, ventral temporal lobe, and precuneus/posterior cingulate, indicating more extensive activation of semantic information with increasing concept familiarity and imageability.

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However, in comparison with existing maps of macaque auditory cortex, activations in human auditory cortex reveal more extensive activations in non-tonotopic regions that are lateral and posterior to the tonotopic representations.

FM patients showed more extensive neural activation in frontal and parietal regions, including bilateral activation in the middle frontal gyrus and right-side activation in medial frontal gyrus, superior parietal lobe, and precentral gyrus.

We also found that activation varied with task demands, with more extensive frontal activation noted in the overt compared to the covert verb inflection task.

Such an increase in overlap may either result from activations becoming more extensive or from activations moving closer together.

The higher number of B cells in TCR-TgA mice could present antigen to T cells more effectively and led to a more extensive T cell activation).

In the NERD-SI group, the three ROI areas were all activated and were more extensive as compared with activation in NERD+.

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