The use of onset offset mode rather than contrast reversal stimulus is more appropriate for the activation of the P-system.
We do not believe, however, that this reservation detracts from the intrinsic value of our observations and of the process, and indeed further experiments may result in more appropriate markers of "activation" which influence cellular migration to be defined.
Randomized controlled trials have demonstrated that interventions to train patients to assume more active involvement in their care and to ask more appropriate and relevant questions ("activation") can improve patients' outcomes[ 25, 26].
Phosphorylation of mTOR by Akt at serine 2448 might not correlate with mTOR activation, therefore, pmTOR may not necessary be involved with the development of HRPC, and a more appropriate marker of mTOR activation could be S6Kinase (Ruggero and Sonenberg, 2005).
This suggests that in the realm of simplified, approximate kinetics modeling of energetic solids, the low gas phase activation energy limit is a more appropriate model than the classical high activation energy limit or heuristic flame sheet models.
These tasks would be better faced by relying on a more appropriate, problem-specific basis of activation functions.
Accumulating evidence suggests that a gene expression signature-based readout of pathway activation is more appropriate than relying on a single gene of each pathway, thus reflecting a complex interplay between the different components that require a more complex analytical approach in order to be visible.
Previous evidence (mainly derived from surgical series and/or in non-erlotinib treated patients) suggests a potential role of pERK and pAKT in pancreatic cancer biology and both markers additionally may represent a more appropriate way to assess EGFR pathway activation compared to single upstream markers like EGFR itself [ 14– 17].
These modifications do not form long chromatin domains in yeast; therefore, a model of small-range spread might be more appropriate for the histone modification associated with activation.
In such cases it may be more appropriate to refer to persulfate decomposition instead of activation, and this is the convention that is followed throughout this manuscript.
