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Getting it right may be one of the key steps towards more effective translation of genomic insights into better therapies.

It is clear that we need more effective translation strategies at the individual and the population levels to control the CVD disease epidemic.

Mapping potential pathways for implementation and exploring the attitudes and interrelations of diverse stakeholders may lead to more effective translation of a novel method of prenatal aneuploidy testing.

The focus on protein interactome networks would be salient for all disease processes and would yield a stronger foundation for the many NIH institute-specific programs seeking a more effective translation to biomarker development.

However, that these best drug candidates fail to be effective clinically [ 19] indicates the necessity to examine the correlation between HCC tumors and cancer cell lines and elucidate their similarities and differences for more effective translation of bench-side discovery into clinical utility.

Our analysis of the EURIKA Study extends these findings to show that lack of risk factor control is responsible for a substantial excess risk among patients already under clinical care, highlighting the need for more effective translation of evidence-based guidelines into routine care.

Similar(53)

Each of these pillars generates, to a great extent, conditions for a more effective and efficient translation of scientific knowledge into action, as well as addressing the challenges set forth by Barkin and Schlundt (2011).

Specific ribosomal protein isoforms (Table 1) and translation-regulating factors (HwFUN12, HwTIF1, HwEFT2, HwTEF1) are synthesized, which could be more effective in the translation of desired transcripts under unfavorable conditions and thereby increase the proliferative potential of the cell.

Knockdown of all three genes together was more effective than blocking translation of any individual Cdx gene, and intriguingly a truncation defect caused by disruption of Cdx1, Cdx2, and Cdx4 together is largely rescued by injection of RNA coding for a synthetic transcriptional activator containing the Cdx4 DNA binding domain [ 23].

This suggests that the selection for more effective and more accurate translation acts primarily through avoidance of the most disadvantageous codon pairs and not through over-representation of the most suitable contexts.

This apparent paradox suggests either that a weak inhibition of translation is more effective for longevity or that rapamycin can extend lifespan by mechanisms other than translation.

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