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The combination also had increased toxicity resulting in more dose reductions, modifications, and treatment delays.
This also translated to more dose reductions and fewer chemotherapy cycles administered for cediranib and chemotherapy.
Despite more dose reductions during the course of treatment, the higher dose regimen (cohort I) was also tolerable.
Japanese patients had more dose reductions (Japanese, 90%; overall, 67.8%), but fewer discontinuations due to adverse events (Japanese, 3.3%; overall, 14.2%).
These episodes were associated with more dose reductions (P = 0.003) as well as a lower likelihood of achieving the target dose (P < 0.001).
There was no significant difference in outcome between the two dose levels but the higher dose of 5-FU was associated with more dose reductions and greater toxicity.
Similar(41)
One or more dose reduction was reported in 31% and 52% of patients in the axitinib and sorafenib arms, respectively, and 77% and 80% of patients in each arm, respectively, had one or more dose interruption (Rini et al, 2011).
Notably, radiation doses are steadily decreasing as more dose-reduction strategies such as prospective ECG-gating, low tube voltage, and automatic tube current modulation are performed [ 78– 80].
Patients with a methylated MGMT promoter had more severe adverse events, requiring more TMZ dose reductions or discontinuations (P=0.007; OR 2.7 (95% CI: 1.32 5.7)).
In the control arm, 32%% of patients had one or more PBO dose reductions or interruptions and 19%% had one or more EXE dose reductions or interruptions.
In the EVE + EXE arm, 74%% of patients had one or more EVE dose reductions or interruptions and 23%% had one or more EXE dose reductions or interruptions.
Related(15)
more job reductions
more staff reductions
more defense reductions
more dose levels
more dose modifications
more dose adjustments
more dose delays
more dose combinations
more price reductions
more cost reductions
more dose arms
more spending reductions
more dose groups
more headcount reductions
measures dose reductions
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