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Note that an important underlying assumption for Figure 1B is that the genes do not have multifunction, i.e., no genes involved have two or more distinct functions (Figure 1C).
Genes with more distinct functions may be expected to be under stronger selective constraint.
It has been suggested that, in general, duplicated genes have a tendency to acquire newer and more distinct functions.
Likewise, FU may well have two or more distinct functions in signaling, represented by different domains, isoforms and protein interactions.
"Moonlighting" proteins that have two or more distinct functions are being discovered at a steady pace which makes this contribution important and timely.
They are believed to have acquired newer and more distinct functions, in the course of evolution, thereby adding to the complexity of various regulatory networks in the cell[ 21].
Similar(54)
So it's a shame they didn't make the two trigger functions more distinct.
Such composite (multimodular) proteins consist of two or more components (modules) encoding distinct functions.
Although there were no significantly overrepresented GO terms in those loci with high values of d N/d S, the overall number of GO terms was negatively correlated with d N/d S. Genes with a greater number of distinct functions may be more constrained because they are more pleiotropic (Salathé et al. 2006), and are thus more likely to disrupt a phenotype deleteriously.
Each phase of a lesson activity is composed of one or more learning cycles, which serve distinct functions in the activity.
These results suggest that 5' methylation and methylation within more downstream regions either have distinct functions or are under independent regulatory control.
Related(20)
more distinct tasks
more diverse functions
more specific functions
more distinct positions
more distinct jobs
more distinct position
more inline functions
more civic functions
more subtle functions
more powerful functions
more distinct subcategories
more specialised functions
more sophisticated functions
more distinct zones
more distinct changes
more distinct films
more distinct countries
more distinct contours
more complex functions
more distinct partitions
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com