Hu's connections seem to serve a more subtle function.
However, although often neglected, extracellular nucleotides exert an additional more subtle function as negative modulators of immunity, or as immunedepressants.
See Box 6. PRISMS might also have a more subtle function.
However, LAG-3 knockout mice do not develop overt autoimmunity, suggesting that it plays a more subtle role in regulating T-cell function than the checkpoint molecules CTLA-4 and PD-1 [ 3, 60].
Secondly, PGRP-SB1 could have a more subtle immune function against a specific natural pathogen of the fly, untested here, or in other immune reactions, e.g. phagocytosis (as published for PGRP-SC1A [33]).
In addition, it has also been shown that under conditions that cause prolonged release of low amounts of ATP, this nucleotide has a more subtle modulatory function, inducing a distorted DC maturation and diminishing the ability of mature DCs to initiate type 1 immune responses.
These studies suggested that Syndecan acts as a co-receptor by presenting Slit to Robo and stabilizing the complex, but the possibility that the highly conserved cytoplasmic domains of Syndecan might have a more subtle modulatory function was not ruled out.
It should also be considered that whilst half maximal effective and inhibitory (EC50 and IC50) concentrations are the conventional means of reporting experimental data, far more subtle reductions in function could have clinically relevant consequences.
In contrast, the DFP variants are likely to result in more subtle changes to function and, we could hypothesise, would be more difficult to detect.
We were interested in measuring the effect of statin administration on both the incidence of liver failure (as defined by SOFA) and on more subtle changes in function.
