We identified four Erg isoforms that are highly expressed in articular chondrocytes and share a commonly spliced exon 3, and three Erg isoforms that share a commonly spliced exon 4 and are highly enriched in ECs.
Given the large number of cases examined, and the small number of available ESTs per gene, it remains possible that the evolutionarily conserved boundary is in fact the more commonly used splice site in JEC21 as well.
Compared with randomly selected genes we find that NMD candidates are more commonly subject to alternative splicing in humans (P = 0.0007832).
Note too that Xing and Lee found that in rodents NMD candidates are subject to alternative splicing more commonly than expected [ 44].
In contrast to Sun and co-workers, who found the AR-V567es to be the most abundant splice variant examined [16], we found the AR-V7 to be more commonly expressed than the AR-V567es in CRPC.
hnRNP I, more commonly known as polypyrimidine tract-binding protein (PTB/PTBP1), is a multifunctional regulator in RNA splicing and processing and is implicated in internal-ribosome-entry-site- IRE-S) dependent mRNA translatinternal-ribosome-entry-site- IRE-S
While an alternative splice variant cannot be ruled out as contributing to the production of sCD25 [14], [14], it is more commonly thought that sCD25 results from a proteolytic cleavage event driven by a family of enzymes collectively referred to as "sheddases".
