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Additionally, there appeared to be more alterations in cell lines.
It is to be expected that increased glucose concentration would lead to more alterations in mitochondrial related genes.
Previous studies have demonstrated that a double centrifugation method resulted in higher platelet concentrations [ 167, 168], but caused more alterations in platelet morphology and was more sensitive to small errors during preparation [ 168, 169] compared with the single centrifugation method.
Whereas immortalized keratinocytes and HPV+ tumor cells were found to have more alterations in immune response pathways compared to the PHKs, seventeen different pathways (out of 35) linked to metabolism were seen in PHKs versus only one (SiHa), two (HaCaT) and three (HeLa) in CDV-treated immortalized cells (Additional file 3: Table S1).
Of the 14 genes used to define 'complex tumors' for that study, we found that all 14 genes had one or more alterations in our tumors, but only MDM2, which had a CNA gain in 12% of cases, was associated with failure to achieve EFS24 (P=0.049).
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It is a foregone conclusion that closer areas of the wellbore have more alteration in permeability rather than far points.
Third, from the protein phosphorylation perspective, in nearly all the GO categories outlined, we identified more alteration in MNNG-treated TK6 cells than in MNNG-treated MT1 cells.
Our ischemic stroke patients showed more alteration in a measure of functional integration in the brain networks: the mean path length, computed as the global average of the graph's distance matrix [Watts and Strogatz, 1998].
Synthetically, primary tumor harbored more alterations located in Wnt, cell cycle, JAK-STAT pathways, which plays an important role in encoding protein molecular emphasizing the cell proliferation, apoptosis and inflammation, as well as focal adhesion pathway.
Conversely, the frequency of CRCs in the group showing three or more alterations was higher in M+ than in M− tumours (34/130=26% vs 9/72=12%; P=0.023).
More alterations were observed in patients of rectal cancer than adenoma, and the numbers of changes were 39.13±20.48 and 14.3±6.164, respectively (Additional file 1: Figure S1).
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