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Importantly and different from sham treated controls, most of the AT8-positive neurons in STZ-treated pR5 mice also stained with the pS422 antibody, suggesting a more advanced pathology.
They reported that patients with UCB have more advanced pathology than those of UUT-UC cohort.
This shift would have many ramifications, including allowing patients with a more advanced pathology into MCI trials.
Methylation of the THBS4 promoter was highest in normal mucosa in patients with normal colonoscopies, and declined progressively as more advanced pathology was evident.
A more recent retrospective study reported that individuals who harbor SSA/P and adenomas have more advanced pathology including cancer compared with patients with adenoma only; however, patients with increased risk or with family history were also present in the study cohort, SSA/P cases included large HP and serrated lesions were not histologically reviewed.
Similar(54)
This finding is consistent with the cognitive reserve theory that more advanced neurodegenerative pathology may be present in patients with higher educational levels than those with lower educational level with the same clinical severity.
12 These patients usually develop the disease earlier and are associated with more advanced α-synuclein pathology.
Younger age at the time of starting ChEI and higher visual scoring of MTA may imply a more advanced Alzheimer's pathology.
A total of 292 patients with more advanced T-disease on pathology or physical examination but no evidence of regional or distant metastasis were classified as stage II melanoma.
In more advanced COPD the extra-pulmonary pathology starts to contribute to disease severity and a vicious circle of persistent difficulty to treat inflammation.
However, the density of neurons in the CA3 was lower in these latter patients than in Patient P9 (38%and42%2% fewer neurons, respectively), suggesting that the CA3 pathology was more advanced in these patients than in Patient P9 (Supplementary material).
Related(20)
more advanced disease
more extensive pathology
more advanced illness
more advanced condition
more serious pathology
more vascular pathology
more severe pathology
more common pathology
more widespread pathology
more advanced way
more pronounced pathology
more dangerous pathology
more advanced configuration
more advanced training
more chronic pathology
more significant pathology
more profound pathology
more fundamental pathology
more advanced state
more diffuse pathology
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