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Contrast computed tomography is useful to localise the site of bleeding and exclude more common pathology [2, 3, 17].
It should be noted that PSP in general is a more common pathology than CBD suggesting a recruitment bias likely driven by the fact that these autopsy cases were mainly from dementia clinics.
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Alzheimer disease (AD) is the most common type of dementia, and mixed pathologies in dementia are far more common than pure pathologies [ 1].
Anterior fusion is more common for single-level pathology in relatively young, healthy patients; and posterior fusion is typically performed on older, more comorbid patients with multilevel disease.
For instance, rare familial AD (FAD) forms have an early onset and many additional genetic and environmental risk factors influence the more common sporadic AD (SAD) pathology [ 13].
Similarly to the VITA study, the brain bank-based Arizona Study of Aging and Neurodegenerative Disorders also emphasized that PSP pathology is more common in the general population than thought and that its clinical presentation varies in relation to concomitant pathologies [ 5, 74].
That surgical treatment was more common in patients with spinal pathology on MRI is unsurprising.
One may assume that SUDEP is associated with more common and more severe developmental pathology causing intractable epilepsy, especially a high prevalence of focal developmental abnormalities.
This finding further suggests that defects in lysosome-related pathways might underlie the pathology of more common disorders.
This is contrary to the study from Nigeria [ 28] that reported abnormal pathology slightly more common in the study subjects with heavy infection than those with light infection.
Plantar plate pathology was more common at the fourth and fifth MTP joints in people with RA, in contrast to the predilection for the second MTP reported previously in people without RA [ 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com