Sentence examples for molecules with poor from inspiring English sources

These results suggest that SVS-1 can serve as a simple, effective delivery platform for molecules with poor solubility and permeability.

Alternatively, if pharmacophores present different structural elements required for the interaction with each target, they can be conjugated with cleavable or non-cleavable linkers, although this strategy often leads to molecules with poor drug-likeness properties [41].

The physicochemical properties of molecules are crucial in determining the success of small molecules in clinical development, yet reports suggest that pharmaceutical and academic sectors often produce molecules with poor drug-like properties.

It was recently demonstrated that HA molecules with poor or truncated glycan structures have similar secondary structures, and exhibit higher binding affinity for cellular receptors and anti-HA antibodies than do the fully glycosylated forms [19].

NBps are charged molecules with poor oral bioavailability, and once in the body, bisphosphonates are taken up by the skeleton.

Several techniques described in this section can be utilized in early stage of drug discovery for salvaging of molecules with poor permeability.

Vancomycin is a relatively large molecule, with poor penetration into the alveolar lining and alveolar macrophages [ 14, 15].

Studies on the prognostic value of HLA-E and HLA-G showed that expression of these molecules correlated with poor prognosis and tumour progression (Ye et al, 2007; Yie et al, 2007a, 2007b, 2007c).

These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult.

On the basis of this analysis, it was concluded that the fewer aromatic rings contained in an oral drug candidate, the more developable that candidate is probably to be; in addition, more than three aromatic rings in a molecule correlates with poorer compound developability and, thus, an increased risk of attrition in development.

The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P =.036).