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At the time of biting, the female mosquito injects saliva containing bioactive molecules which facilitate the blood meal and some of these are antigenic [17], [18], [19].
HIV also increases the expression of a number of adhesion molecules, which facilitate binding and diapedesis across the blood brain barrier.
TNF-alpha stimulates the expression of chemokines and adhesion molecules, which facilitate the passage of leukocytes from the circulation into the subarachnoid space.
Elevated inflammatory cytokines circulating in cancer patients stimulate the expression of adhesion molecules which facilitate interactions between metastatic cells and target organs [ 47].
The activated endothelium is characterized by vascular hyperpermeability and increased expression of adhesion molecules, which facilitate perivascular inflammatory cell infiltration [ 29].
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The combination of these features creates an environment within the dendrimer molecule which facilitates trapping of guest species.
Thus, a small molecule which facilitates chloride channel opening, the potentiator Ivacaftor, has been approved for the treatment of CF patients bearing a particular class of rare CFTR mutations.
A second important molecule for signaling through TLR1/TLR2, TLR6/TLR2 or TLR4 is TIRAP, a sorting adapter molecule which facilitates MyD88 recruitment to the plasma membrane [ 25].
Utilization of glucose with an azide group (N3) allowed further modification such as addition of a biotin molecule, which facilitates enrichment.
Thus, the CD54 molecule which facilitates leukocyte-endothelial transmigration is more abundant on monocytes, while the HLA-DR molecule responsible for the presentation of foreign peptide Ags to the immune system is less.
Lastly, we examined ICAM-1, an endothelial adhesion molecule which facilitates adhesion, arrest and transmigration of leukocytes and demonstrated that myometrium expresses greater amounts of ICAM-1 during labour, compared to immediately prior to parturition [ 5].
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