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Apart from VEGF, other molecules can stimulate neurogenesis, oligodendrogenesis and angiogenesis.
Cases where some other molecules can stimulate HIF-dependent angiogenesis have been demonstrated.
These data suggest that double as well as some single-stranded linear DNA molecules can stimulate ATM activity.
Certain β-lactam antibiotics, identified by a high-throughput screen of small molecules, can stimulate the expression of astrocyte glutamate transporters sufficiently to reduce excitotoxicity and neuroprotection in models of stroke and ALS [ 199].
In this context, prior work has shown that a collection of small pyrophosphate-containing organic molecules can stimulate human Vγ9Vδ2-expressing γδ T cells (also referred to as Vγ2Vδ2 by the Seidman et al. nomenclature) in vitro in a TCR-dependent manner (Chien et al., 2014).
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This study shows that HEL2i-domain mediated scanning allows RIG-I to sense the length of RNA targets, and a short RNA duplex that binds one RIG-I molecule can stimulate ATPase activity and interferon response.
Insulinotropic peptides are various kinds of protein molecules that can stimulate insulin secretion by the pancreatic islets β-cells through different pathways.
PAMPs are foreign molecules that can stimulate PRRs such as the Toll-like receptors.
Paradoxically, there is also interest in identifying small molecules that can stimulate HIV transcription.
Recent evidence has revealed that the MMPs not only cause degradation of the ECM but also interact with adhesion molecules and can stimulate cell migration and invasion.
TAA captured by antigen-presenting cells (APCs), such as macrophages or DCs, are generally processed into peptide fragments in acidic endosomes and presented them in conjunction with class II MHC molecules that can stimulate CD4+ helper T lymphocytes (Th), but not CD8+ CTLs restricted by class I MHC [ 2].
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