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Each odor molecule can activate multiple odor receptors (ORs), and OSNs expressing the same OR converge onto just a few glomeruli [15] [20].
This molecule can activate the PI3K/AKT pathway to cause FOXO3a to translocate to the cytoplasm of mammalian cells [ 27].
Each enzyme molecule can activate many molecules of prodrug, which results in large amounts of drug generated at the tumour (amplification effect).
Responsive switching may also have a stochastic component as fluctuations in the level of a key regulatory molecule can activate the switch once a threshold level is crossed [ 1, 3, 5, 6].
Moreover, several groups including ours have shown previously that several peptides that do not fit the consensus sequence for peptides binding to a given MHC molecule can activate T cells restricted to that MHC molecule very efficiently [ 33- 36].
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Moreover, microarray gene expression analysis of MDA-MB-231 cells after expression of E- and P-cadherins revealed that these molecules can activate signaling pathways leading to significant changes in gene expression.
These molecules can activate the clotting cascade (Coa) (Panizzi et al., 2006), mediate binding to host tissues (Cna, Eno, FnbA and FnbB) (Patti et al., 1992; Greene et al., 1995; Carneiro et al., 2004), and sequester host antibody (Spa and Sbi) (Forsgren and Sjoquist, 1966; Zhang et al., 1998).
In antigen-stimulated mast cells, Src family kinases such as Lyn and Fyn are activated and subsequently phosphorylate Syk, a central signaling molecule that can activate the downstream signaling molecules including PLCγ1 and MAPKs [ 30].
Spd may act as a kind of multi-functional signaling molecule that can activate a variety of defense reactions, resulting in maintenance of normal metabolism and enhanced resistance (Groppa and Benavides [2008]).
Thus, a small molecule that can activate SERCA and maintain high ER calcium levels under pathological conditions could prevent death of neurons and β cells in Wolfram syndrome.
To identify small molecules that can activate p53-responsive transcription, we performed chemical screening using genetically engineered HCT116 reporter cells.
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