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One of the Mg2+ ions attacks the water molecule, and subsequently water ionizes, the proton forms a bond with Lys73 and the OH group forms a bond with the phosphorus atom.
The models were first improved using rigid body refinement of each RNAP molecule and subsequently of 20 individual mobile domains using PHENIX (Adams et al., 2010).
This model was based on two displacement loops (D-loops) separated by some distance on the genome, where the displacement of the two D-loops occur on opposite strands of the parental DNA molecule and subsequently, move towards each other.
Also, the proliferative response is initially confined to limited regions on the GAD65 molecule and subsequently spreads intramolecularly to different regions of GAD65 and intermolecularly to other β cell antigens such as insulin [ 51].
The processed small peptides are then transported into ER lumen by transporter for antigen processing (TAP) complex, loaded onto MHC-I molecule, and subsequently exported via classical secretory pathway to the cell membrane [ 27].
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The models were built using the training set molecules and subsequently validated by test set molecules.
Here we present a straightforward route to functionalizing the SAFs with small molecules and, subsequently, other moieties.
Some of the altered amino acid peptides can be expressed, processed, and presented on the cell surface by MHC molecules and subsequently recognized by T cells.
The signal mechanism which referred to cascade events in cells included early oxidative stress signal transmission molecules, and subsequently transcription modulator STAT1.
This indicated that the conformation of the ribozyme core remains active despite the absence of the effector molecules, and subsequently, remain unaffected with the presence of either one or even both of the effector molecules.
The consistent perturbations of the surfactant monolayers caused by the high kinetic energy resist the formations of any organized layer of surfactants molecules and subsequently lead to the low adsorption at high temperatures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com