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To understand better the structure/property relationships governing polymeric gene delivery, we synthesized polymers with 70 different primary structures, at 6 to 12 different molecular weights, using monomers previously identified as common to effective gene delivery polymers.
The model elastomers with controlled lengths of the network strands and known amounts of cross-links and dangling chains are obtained by end-linking the functionally terminated precursor PDMS with known molecular weights using multi-functional cross-linkers.
Viscometry enables the determination of molecular weights using a universal calibration curve.
ASTRA 6.1 (Wyatt Technology) was used to calculate molecular weights using the Zimm equation.
The crude oligosaccharides were further fractionated based on their structural and molecular weight properties (neutral/acidic, different DP and molecular weights) using size exclusion chromatography.
Here, we investigate the effect of decreasing dimethyl sulfoxide (DMSO) concentrations in cryosolution by substituting with hydroxyethyl starch (HES) of different molecular weights using different freezing rates.
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The predicted phase diagram has upper critical solution temperature (UCST) behavior with a critical temperature of 143 °C for the molecular weights used in this study.
Table 2 summarizes the fractional urinary excretion estimates as well as the molecular weights used in the analysis.
The emulsions prepared thereof were characterized for particle size, zeta potential and molecular weight using gel permeation chromatography.
This work reports the preparation and study of poly vinyl chloride) (PVC) with medium and high molecular weight using a Living Radical Polymerization (LRP) method in aqueous systems.
Grafts were characterized through molecular weight using GPC, melting temperature and enthalpy of melting by DSC and chemical structure through 1HNMR.
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