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A column can be calibrated with polymer samples of known molecular weight so that the time required for emergence of the unknown mixture can be used to deduce the molecular weights of the components of the sample as well as their proportions; such molecular weight distributions are very important characteristics of polymers.
Since both siRNA and aptamer are RNA molecules and often share similar molecular weight, so it is hard to design cationic delivery vehicles that selectively bind to the siRNA, leaving the targeting exposed aptamer.
The ordered β phase occupied less volume compared to the α phase as the β conformation was more planar and packed tightly, and the proportion of β phase was more in aggregation of high molecular weight, so the aggregation size of high molecular weight was smaller than that of low molecular weight.
PSVue 794 has a low molecular weight, so it can distribute through the circulation with less hindrance than the larger annexin V.
As discussed above, the density of the polymer domain decreases with increasing molecular weight, so the intrinsic viscosity is a sensitive measure of the molecular weight.
Vieira et al. showed that the decrease in tensile strength of the copolymer PLA-PCA follows the same trend as the decrease in molecular weight, so a first order equation can be used to model the change in mechanical properties with degradation [ 18].
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Nylon was chosen for this work because it attains good mechanical properties at relatively low molecular weights, so limiting the extent of chain propagation necessary.
Further, not all gelatins are equal; they come from different sources and have widely differing molecular weights, so the range of possible junction types may differ significantly between products.
K5 and MARCH-IX form SDS-stable high molecular weight complexes so that very little protein corresponding to the predicted molecular weight is recovered (see also Fig. 2E).
Accordingly, kinase inhibitor development has been one of the major focuses of drug development during the past two decades [3 5], a considerable effort that led to the approval of 8 low molecular weight drugs so far.
The molecular weights of so-obtained PMMA were high and polydispersities were quite narrow (Mw/Mn=1.20 1.31).
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