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Due to its small molecular size it can over come the poor permeability of β-lactams for Pseudomonas by efficient penetration through the porin, OMP D [ 34].
While FRAP can report changes in molecular size, it provides no information on the composition of molecular complexes.
Since GFP was bigger than PRL-3 in molecular size, it might produce steric hindrance for correct localization of PRL-3.
Considering that TOY3 has a slightly higher production rate and smaller molecular size, it will be the most favorable construct for therapeutic use of TOY in the future.
Although chemotherapeutic agents are unlikely to cross the blood brain barrier (BBB) due to their molecular size, it has been alleged that the occurrence of neurotoxicity is linked to the proinflammatory cytokine pathways.
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Depending on the nature of the substrate its molecular size and whether it contains any polar group the disulfide, which is the coupling product, may be soluble or sparingly soluble in water.
Thus VRK2 protein level increases in the high molecular size fractions while it decreases in the small molecular size fractions.
Furthermore, based on such relations between molecular size and enantiomeric discrimination it may become possible to predict the minimal size of prebiotic molecules that would generate sufficient symmetry breaking as inferred from the C-GARD model.
Second, several important factors most certainly center around differences in molecular size, in particular, as it relates to the large taxane binding pocket and the discrepancy between the 3D space occupied by taxol and the simplified ligands.
Substitutions of conserved Gln155 by Asn and Glu159 by Asp only result in subtle changes in the initial structures at the MHR because Gln vs Asn and Glu vs Asp have similar molecular size and hydrophobicity; thus, it is expected that these mutations would neither introduce large new interactions, nor alter backbone conformation.
Compared with the polystyrene, which has a molecular weight of 2×106, the molecular size is only 96 nm, it is undoubtedly a super macromolecule.
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